PREPARATION OF 5'-PHOSPHORIBOSYL-5-AMINO-4-IMIDAZOLECARBOXAMIDE
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چکیده
منابع مشابه
The effect of 4-amino-5-imidazolecarboxamide on the toxicity of 8-azaguanine.
The guanine analog, 8-azaguanine, has been shown to possess carcinostatic properties against transplantable tumors in experimental animals (7, 8). I t was believed that the compound inhibited the proliferation of tumor cells by acting as an antimetabolite in the biosynthesis of nucleic acid purines of the neoplastic tissue. To elucidate the mechanism of action of the drug, the possibility of an...
متن کاملEffect of 5-amino-4-imidazolecarboxamide riboside on renal ammoniagenesis. Study with [15N]aspartate.
[15N]Aspartate and 5-amino-4-imidazolecarboxamide riboside (AICAriboside) were used to evaluate the contribution of the purine nucleotide cycle to ammonia production in renal tubules isolated from control and chronically acidotic rats. Addition of 1 mM AICAriboside to incubation medium containing 2.5 mM [15N] aspartate significantly stimulated production of 15NH3 and 15N in the 6-amino group of...
متن کاملThe Incorporation of Radiocarbon from 4-amino-5- Imidazolecarboxamide into the Purines of Tumor-bearing
The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
متن کاملThe incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide into the purines of tumor-bearing mice.
The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
متن کاملInhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes.
5-Amino-4-imidazolecarboxamide riboside (AICAriboside; Z-riboside), the nucleotide corresponding to AICAribotide (AICAR or ZMP), an intermediate of the 'de novo' pathway of purine nucleotide biosynthesis, has been shown to inhibit gluconeogenesis in isolated rat hepatocytes [Vincent, Marangos, Gruber & Van den Berghe (1991) Diabetes 40, 1259-1266]. We now report that glycosis is also inhibited ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65808-9